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The General Introduction of Gene Synthesis

Standard gene synthesis is the process of artificially synthesizing double-stranded DNA molecules in vitro as a technique for getting target genes. It is characterized by short synthesis cycle and is not limited by the source of the template. Gene synthesis is widely applied in various fields, including genetic engineering, synthetic biology, and biomedical research, enabling scientists to study, modify, and even create new genes and organisms.

A leader in Custom Gene Synthesis Solutions

Synbio Technologies is committed to providing customers with fast, accurate and reliable custom gene synthesis solutions. With ten-billion-base synthesis experience and advanced vector design platforms, we can skillfully overcome complex gene synthesis challenges, including high/low GC content, repetitive sequences, hairpin structures, etc. With our gene synthesis service, customers can also enjoy free codon optimization, vector build and storage services.

Benefits of Our Gene Synthesis Service

Our products are of the highest quality and competitively priced. We guarantee 100% accuracy in DNA synthesis and cloning into your desired vector! With our DNA synthesis technology, you can achieve fast gene synthesis to meet the needs of various artificial gene synthesis and gene synthesis applications.

Highlights

Optional

Free codon optimization, vector build, and storage
AI-powered

Perfect solution to complex gene synthesis
Cost-effective

Lower prices and faster TAT
Accuracy

Deliver 100% accurate DNA sequences

Service Details

Service Types	Gene Length	Price	Turnaround Time (Business Days)
Standard Gene Synthesis	<251 bp	$50	5-10
	251-1,500 bp	$0.20/bp	5-10
	1,501-3,000 bp	$0.21/bp	10-15
	3,001-4,500 bp	Quote	15-20
	4,501-6,000 bp	Quote	20-25
	6,001-8,000 bp	Quote	Quote
	>8,000 bp	Quote	Quote

* Turnaround time applies to gene synthesis of non-complex sequences. For gene synthesis of complex sequences, please consult: quote@synbio-tech.com.

* Optional protein validation with ProXpress.

QUOTE

How Gene Synthesis Ordering System Makes Everything Easier？View More

Intelligent Sequence Complexity Evaluation

Our new system uses advanced algorithms to automatically analyze sequence complexity, providing detailed information about your gene without the need for manual calculations.

Protein Sequence Optimization
With a built-in protein sequence optimization module, the power to significantly improve both the stability and expression efficiency of your gene sequence is in the palm of your hands.

Real-time Quotes

Simply input your gene sequence and our system will automatically calculate the synthesis cost based on length, complexity, etc., providing a valuable project budget reference.

Our new gene synthesis order system is designed to revolutionize the way you synthesize genes. With a user-friendly interface and streamlined quotation process, ordering custom genes has never been easier. Your access to better, smarter genes is finally here!

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Deliverables

2~5 µg lyophilized plasmid DNA

Sequencing chromatogram

Certificate of analysis (COA)

Case Study

A case of complex gene synthesis and assembly for a 14kb fragment

Successfully synthesized a 14kb complex gene fragment and assembled the synthesized gene of interest onto pSynoYac0-Cm (approximately 10kb).

Difficulty Analysis of CI System

● The GC content in the target fragment fluctuates significantly, with some regions reaching as high as 100%.

● There are multiple repetitive sequences present within the target fragment.

GC Content Analysis of the Target Fragment

Repeat Sequence Analysis Chart of Target Fragment

FAQs

What are the factors that affect gene synthesis?

The factors that affect gene synthesis are primarily determined by sequence length, DNA structure, (including repetitive sequences, GC content, and other factors), and host cell stability.

What is frameshift mutation?

Frameshift mutation occurs when the amount of nucleotides in a gene increases or decreases by a number that is not a multiple of three. Since three nucleotides encode for one amino acid, this alteration causes a shift in the reading frame of the DNA sequence. This results in the production of a non-functional or altered protein that differs from the intended one.

What is codon bias?

Codon bias refers to the unequal usage frequency of synonymous codons (codons that encode for the same amino acid) among different organisms. Understanding codon bias is crucial for optimizing gene expression in specific hosts.

More FAQs>>

Resources

Brochure & Flyers

Guide & Tools

Bioinformatics Tools
DNA Studio

Specific Applications

Gene synthesis has a wide range of applications, including genetic engineering, synthetic biology, biomedical research, and more. Click Emerging Applications for Large De Novo DNA Synthesis to learn more:

• Genetic Engineering

With custom gene synthesis, unique genes can be created and inserted into vectors for gene cloning, making functional studies and gene expression easier. In addition, with gene synthesis services, specific genes can be synthesized and inserted into plant or animal cells to generate transgenic organisms with improved crop resistance or biological traits.

• Biomedical Research

Gene synthesis service provides artificial gene synthesis solutions and supports a variety of gene synthesis applications to meet clinical needs. Through custom gene synthesis, specific genes of pathogens are synthesized for vaccine development and immune response enhancement. Therapeutic genes can also be synthesized and introduced into patient cells to correct genetic defects or treat diseases.

• Synthetic Biology

Through advanced DNA synthesis technology, new gene circuits and regulatory elements can be synthesized to construct biological circuits to achieve precise control of cell behaviour. Gene synthesis can also be used to create new metabolic pathways, enabling microorganisms to produce drugs, fuels or other valuable compounds and exert new biological functions.

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