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The General Introduction of RNA Modification

Synbio Technologies offers a wide range of modification options for synthetic RNA, providing customers with flexible and diverse choices, including fluorescent labeling. RNA modifications enhance cellular delivery, stability, and resistance to nuclease degradation with options like phosphorothioate, 2’-OMe, and 2’-F modifications. Fluorescent labeling allows for the observation and localization of RNA using fluorescence and confocal laser microscopy, and serves as a tool for virus detection, disease diagnosis, and early tumor screening.

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Delivering optimal customized RNA synthesis solutions
Various Modifications & Fluorescent Labeling

Tailored RNA modifications and fluorescent labeling to meet our customers’ needs
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RNA Modifications and Fluorescence Labeling

RNA Modifications		RNA Fluorescence Groups/Quenchers Labeling	Dual/Multiple Labeling
Modified Bases	• 2′-O-Methyl • 2′ Fluoro • m6A	• 5’ Cy3 • 3′ Cy3 • 5’ Cy5 • 3′ Cy5 • 5’ FAM • 3′ FAM • 5′ ROX • 3′ ROX • 5’HEX • 5’TAMRA • 5’TET • 3’BHQ-1 • 3’DABCYL • 3’TAMRA	• 5′ FAM-3′ BHQ1 • 5′ HEX-3′ BHQ1 • 5′ TET-3′ BHQ-1 • 5′ FAM-3′ MGB • 5′ FAM-3′ TAMRA • 5′ HEX-3′ TAMRA • 5′ TET-3′ TAMRA • 5′ HEX-3′ MGB • 5′ TET-3′ MGB • 5′ FAM-3′ DABCYL • 5′ HEX-3′ DABCYL • 5′ Phos-3′ FAM • 5’TAMRA-3’Phos • 5’C6-Biotin-3’Cy5
Phosphorothioates	• P-S
Phosphorylation	• 5’- PHO • 3′- PHO
Amino Linkers	• 5’-NH2 C6 • 3’-NH2 C7
Thiol	• 5’-SH C6 • 3’-SH C3
Biotin	• 5′ Biotin
Digoxigenin	• 5′ DIG • 3′ DIG

QUOTE

FAQs

What is the significance of RNA modifications in disease?

Dysregulation of RNA modifications is associated with various diseases, including cancer, neurological disorders, and metabolic syndromes. Understanding their roles in disease pathology may lead to novel therapeutic strategies.

Why are RNA modifications important?

RNA modifications play crucial roles in regulating gene expression, RNA processing, translation efficiency, and RNA-protein interactions. The modifications contribute to cellular differentiation, development, and response to environmental stimuli.

Are RNA modifications conserved across species?

RNA modifications are generally conserved across species, indicating their fundamental roles in cellular processes and gene regulation. While specific patterns and levels of modification may vary between species, the presence of conserved modifications underscores their evolutionary significance and functional importance in maintaining biological integrity and adaptability across diverse organisms. Understanding these conservation patterns is essential for deciphering the regulatory mechanisms governed by RNA modifications and their implications in health and disease.

RNA Modifications and Fluorescence Labeling

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